Jarrow FormulasSame 400 mg - 60 Tablets - Highest Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Mood & Antioxidant Defense - 60 Servings

I have used Amazon for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience.First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

Since COSTCO no longer carries Sam-e, I get it here on Amazon.

Ever since a vet recommended this product for a geriatric dog, I've used it for numerous elder dogs since then. It is also wonderful presurgery (check with your surgeon of course) and after any kind of stress or recovery. I was a Foster home for a breed rescue for many years and this is part of my arsenal to help dogs get part transition stress.To me, seeing the clear results in dogs negates any thought of a placebo effect. Plus, it's backed by enough peer reviewed studies that vets at least prescribe it with confidence.Not this brand,but I have taken care to ensure that the brand I use matches the $80(!) Prescription quality precisely.Narrow is the one I trust the most, but there are other brands which are also excellent. What you want is:Made in USA. Even from some of our friends I suspect the potency, and from China you may as well plant them in the ground like magic beans. No offense to individuals from China, but supplements sourced from those manufacturers are consistently lacking in actual active ingredient. :(Enteric coating. The active ingredient is absorbed in the colon, so must pass the stomach. It will also give you a massive belly ache!Blister packaging or some other way to seal the tablets individually. The active ingredient is highly volatile. It is sensitive to light, oxygen, heat, and moisture. Also, you want to avoid scratching or chipping the coating.The directions say take on an empty stomach and wait thirty minutes before food. The minute you wake up is the best time. Nothing should be down there triggering extra digestive action.All this is totally worth it. I have three dogs, one twelve,one thirteen, one eighteen. The twelve and thirteen year older still play Frisbee, I mean really play, like jumping and stuff. The eighteen years old still requires her daily walks and training time,or she gets into trouble, countersurfing or removing the kitchen trash from the LOCKED cabinet.The only other thing I do for them in terms of supplements is melatonin at night to ensure correct sleep patterns.