Seeking Health Active Vitamin B12 Supplement Lozenge With L-5-MTHF

My labs have improved and it tastes great

A little on the high side price-wise, but it works very well. Maybe too well. After having had a vitamin B12 deficiency for years, we started taking Seeking Health Methyl B12 every day. And as it turns out, every day is too often lol. Because within a year, the vitamin B12 deficiency was not only addressed, but the latest labs show very high levels of B12. So now we only take it once a week. We will update this review after the next lab appointment. If you have a B12 deficiency or insufficiency and have trouble with bioavailability of most forms of B12, this will really work well for you. And if you have MTHFR as I do, you can take this without the unpleasant side effects you will often get from other forms of B12.

I have suffered from constant fatigue, joint pain and a number of other disorders and chronic illnesses for years. I have been tested for hypothyroidism, gluten intolerance, and anything else doctors could think of, but no one could find a reason for my symptoms. I finally got an answer when a gene methylation analysis showed I was homozygous for the MTHFR C677T mutation, as well as for COMT V158M and COMT H62H mutations. Doing research, I found that suddenly my symptoms made sense, and had a cause I could pinpoint! The MTHFR C677T mutation alone means that I cannot break down folic acid into folate, nor can I break down folate effectively into 5-MTHF, the bio-available form of folate. My methylation cycle has been crippled by this genetic mutation to a large degree. Various other issues (antacid use and gastrointestinal troubles) have led to me being deficient in B12 as well. I stopped taking my folic-acid containing multivitamins, stopped eating folic acid fortified foods, and bought these B12 lozenges with L-5-MTHF. You know how when you first take a new supplement you wonder after a few days or weeks if it's really working? That was NOT the case with this sublingual supplement! I swear, the very first dose I took saw me with more energy than I have had in years. I'm fully off my multi now (and have an appointment with a specialist to figure out the exact dosages I need to take of what types of supplements to help with this genetic mutation) but I feel better on this one supplement alone than I have since I was in my early twenties. My chronic achilles tendinosis? Well, not completely gone, but I'm finally having pain-free days. My shoulder and hip joint pain has decreased. My heat intolerance has all but disappeared. I actually stood up and mingled, socially, at an outdoor work event in 96 degree heat for 5 hours without feeling faint or sick! Best yet, I'm sleeping only 8 hours a night now and I don't need to take naps in the middle of the day. I started out on one tablet and am working my way up to 2-3 tablets a day sublingually. I will take one as soon as I wake up, and in 10 minutes I feel too alert to stay in bed any longer. Then I'll take another one a couple of hours later, and finally a last one right as I start to get the "post-lunch coma" around 2pm. I've already ordered another bottle. I don't know yet what my full supplement regimen will be to best manage the expressions of these various gene mutations, but I feel like I'm already 75% of the way there with this product! I feel 15 years younger.

good taste, melts under the tongue.

I have a severe yeast allergy (to Saccharomyces cerevisiae aka baker's yeast, brewer's yeast, active dry yeast, etc) and have used this B12 product safely, with no issues, but I still only take 1/4 of a lozenge (because I don't want a mega dose of B12 at a time and I take 1/2 or 1/4 of a lozenge every 5-7 days. To break it, I put it in a plastic baggy, and break it on the edge of the table in half, and then in half again) I saw in the "questions" area that people were asking about yeast and why it doesn't say "yeast-free" ...I can probably help with this and will explain --- the reason it doesn't say "yeast-free" is likely due to xylitol in the inactive ingredients, although there is likely no yeast remaining and minimal to no yeast proteins. This product is a lozenge, so I felt safer trying it, although it doesn't specifically say yeast-free, but due to my science background and understanding of manufacturing practices, I assumed the risk was very low, since B12 is generated via bacterial fermentation, and xylitol is the culprit here (to why it doesn't say "yeast-free"), as it can be produced using bacterial fermentation, yeast fermentation, mixed cultures of both, or fungi, or enzymatic reactions, but there should be no yeast in the end product that is sold as food-grade xylitol for companies to use in their products. To try this product, I broke one lozenge into 4 pieces and put 1/4th piece inside of my lip between lower teeth and lip. An allergy doctor told me to do this to try things if it should be safe, but if I am unsure, since that is a highly vascular region with thin skin where absorption is quick, so you'd know from skin changes/mouth feeling if it is not safe, could reverse with medication at that point, and would not have ingested it into digestive system. =================== Manufacturing B12 and Xylitol... Let's start with B-12: Vitamin B12 that is laboratory made uses bacterial fermentation, like Lactobacillus strains. (Not yeast fermentation --- yeasts cannot make B12). Luckily, yeasts do not create B12...so would not be used in manufacturing of B12. Moving to Xylitol... Xylitol is a sugar alcohol, it's complex to produce commercially...there are a variety of steps to create D-Xylose, and from here, Xylitol is produced from D-Xylose using either yeast, bacteria, fungi, or mixed cultures of both yeast and bacteria, or enzymatic reactions... so the supplier of xylitol for this product likely doesn't say it's yeast-free, but even if yeasts were used, yeast would be separated and removed in the creation of food-grade xylitol. Most xylitol manufacturing, if using yeast-containing cultures, would use Candida yeast strains (which most people cannot be allergic to, since naturally in our bodies and on our skin, our body keeps these in certain levels since we need but also don't want over-growth) but this would be removed in processing steps, anyway. Most yeast allergies are to Saccharomyces strains, which aren't usually used in xylitol processing because they yield much less xylitol at the end compared to Candida strains. There is also a chance that the xylitol is produced using a completely different process (hydrolysis, but that involves a lot of solvents, reagents, purification steps and separation steps and was expensive so companies began looking into ways using the above explained microbiology practices using micro-organisms) and there is no yeast involved at all in the hydrolysis super manufacturing of xylitol... but we'd need the company to tell us where they source their Xylitol from, and we could look that up about which processes they used.

I'm on my second bottle, and no complaints. Obviously there's no way to scientifically verify my experience, but I believe this supplement is helping me. I bought it based on research on the most easily absorbed forms of B12 and Folate, and this seemed to offer both of those for a better deal than I could find elsewhere. I have not been tested for the MTHF gene, but my sister has tested positive for it. I have had symptoms of B12 deficiency for some time, including anxiety and a stubborn predisposition to canker sores. Anxiety is more complex for me, but my tendency to develop canker sores has changed since taking this supplement (which it *had not* when I was on a high-dosage regular B-12). In recent years, basically any wound to my lip or cheek would become a sore, and I had variously effective methods to try to keep them at bay. It was a constant battle, however, and nothing seemed to get to the root of the actual problem. What I've noticed since taking this supplement (it's been about 4-5 months) is that I have not had to fight off canker sores every time I bite my lip or cheek. That's significant. In fact, I don't remember the last time I had to use one of my remedies to treat a developing sore. They seem to heal much better. My anxiety is better recently, but I believe that's due to more general lifestyle changes -- to which I would expect this supplement might be contributing in some way. But I can't tell you for sure how, or how much. Taste wise: I don't usually care for cherry, but this one is relatively inoffensive. It's nice that it's dissolvable since I hate swallowing pills. I recommend this product if you have the MTHF gene, or if you appear to have a B12 absorption problem. It seems to be good quality and effective, and it uses specific forms of active B12 that have been tested to be among the more efficiently absorbed. There are other active forms, but my research led me to settle on this one. Good luck and I hope this was helpful!

They're relatively small, circle pills, that crack if you bite into them and are chaulky. I swallow mine, but my son chews them. He says they taste gross, but he does it anyways with water. I'd say as long as you or your child can swallow small pills these are fine. We started these right before my son went on Spring Break, so I could monitor if there were any changes. I didn't notice anything for about 10 days, but he said he felt good and had energy. Almost 3 weeks in, he told me he didn't have autism anymore (not true! he still does!!!). I asked why and he said, "He doesn't feel like anything is wrong." So, I ordered another bottle. Who is to say what is making him feel better, but this vitamin is the only change that we've added to his intake. I doubt everyone would have the same results, but they seem to be working for him. So, I'm taking them now too and so is my mom. I don't feel any side effects and I have felt a bit more energized in the afternoons when I usually want to nap. I certainly don't want to say they're miracle vitamins, so please don't misunderstand my review, I just wanted to share our experience. I do like them and my entire family is taking them. We are all being tested for the MTHFR gene mutation this summer, so maybe that has something to do with it. My understanding is that these are made from Folate and not Folic acid, which is why we purchased them in the first place. I'm not a doctor, just a mom. So, please take this info as you will. I will add an update if there are any changes to report.

I’ve suffered with a burning tongue sensation for 2 years almost and tried others vitamin brands but nothing helped as much as this one did. After taking this for a week the burning sensation went away. I also noticed I have more energy. Definitely recommend if your b12 deficient like I was.