THORNE - 5-Hydroxytryptophan (5-HTP) - Serotonin Support for Sleep and Stress Management* - 90 Capsules

tryptophan and 5HTP supplements have occasionally been shown to have a contaminant that has become known as "peak X" (due to the mysterious peak on HPLC spectroscopy) that can literally destroy your life, as it can trigger a permanent autoimmune disorder where eosinophils go crazy and infiltrate your muscles called Eosinophilia–Myalgia Syndrome (EMS).Thorne is one of the few companies that specifically screen for this contaminant before selling a batch of 5HTP. I am very grateful that they do this, as it means I can take it with confidence and without worry.5HTP has dramatically improved my sleep. My Apple Watch shows a doubling or tripling of deep sleep/stage 3 sleep when I take 100-150 mg of this at bedtime.

I have been tapering from 60mg of Cymbalta (I'm down to about 2.5mg now) for almost 3 years. It's been totally brutal and horrible despite how slow I have taken it. I've been taking 5htp since I got down to about 25mg of Cymbalta. THERE IS NO WAY I would ever make it through the taper without taking this 5htp.Not all 5htp brands are equal. This is the best one I have found, probably because it has the methylated B-6, and because Thorne is a generally a good quality brand to begin with. Cymbalta is an SNRI- the 5htp only boosts serotonin and not norepinephrine (just a side note, on the off chance that someone reading this is tapering off an SNRI), but still, I can't emphasize enough how much it has helped me. There are other supplements one can take to help with Norepinephrine...I haven't found one that works for me yet, but everyone is different. Also, other vitamins I take, such as vitamin d, methylated b12, and methylated b complex, have been game changers.My son (17) also has depression and anxiety. He takes this 5htp, a super high quality fish oil, vitamin D, methylated vitamin b complex, and a multivitamin. He is literally two different people depending on whether he is taking his supplements regularly (we're on good streak currently, he's been taking them nearly every day for over two months and is feeling great).I almost never write reviews, but something told me to tonight. Who knows, maybe it will help someone. :)

This product helps me have relaxing sleep and without a drugged feeling when I wake up.

I’ve bought a few different vitamins from this brand and they’re always good quality and the perfect amount in each capsule.

I've suffered from insomnia for many many years. I have hashimoto's thyroid disease, low progesterone and adrenal insufficiency. I also carry the MTHFR genetic mutation and am homozygous for C677T. So, I have some issues that I've been dealing with.I used to be able to fall asleep but was unable to stay asleep. I only slept 90 minutes at a time and then when I woke up, I would be up for over an hour before I could fall back to sleep. Then in the last year, I've had trouble falling asleep as well. I tried everything. I tried magnesium glycinate, melatonin, benadryl, ashwaganda, several products from health food stores, gaba....you name it, I've tried it. My doctor tried to shove anti-depressants on me but I'm not depressed. I just cannot sleep!Enter 5-HTP. Wow. As a last resort, I tried this supplement. It's not cheap, but it is the first thing that has worked for me. It took me taking 4-6 pills per day for a month and now I have actually been able to sleep 4-5 hours straight! That is unheard of. It's like a miracle. And, I notice I am dreaming too. I don't think I was ever getting into a deep enough sleep to dream before, but the 5-HTP seems to be helping me get a better quality of sleep in addition to helping me sleep.I wish this wasn't so expensive though as you can quickly go through a bottle in less than a month and if you take 6 pills per day you can run through the bottle in two weeks. I am going to back off to 3 pills per day and then 2 and see if I can still sleep. If I can't, I will have to go back to the higher dosage. I like Thorne Research products and I also take 5-MTHF for the MTHFR mutation as well as selenium. Thorne's products are always high quality.

I use this daily and when I take time off I definitely notice a shift in mood. It’s not a miracle pill but used in combination with other healthy lifestyle routines I’m a big fan

I've been incorporating this supplement into my routine and have noticed a positive impact on my overall mood and sleep quality. Taking it in the evening helps me unwind and promotes a more restful night's sleep. The capsules are easy to swallow and don't cause any digestive discomfort.​While individual experiences may vary, for me, this product has been a valuable addition to my wellness regimen.