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# Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

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The devastating truth about the effects of wheat, sugar, and carbs on the brain, with a 4-week plan to achieve optimum health. In Grain Brain , renowned neurologist David Perlmutter, MD, exposes a finding that's been buried in the medical literature for far too long: carbs are destroying your brain. Even so-called healthy carbs like whole grains can cause dementia, ADHD, epilepsy, anxiety, chronic headaches, depression, decreased libido, and much more. Groundbreaking and timely, Grain Brain shows that the fate of your brain is not in your genes. It's in the food you eat. The cornerstone of all degenerative conditions, including brain disorders, is inflammation, which can be triggered by carbs, especially containing gluten or high in sugar. Dr. Perlmutter explains what happens when the brain encounters common ingredients in your daily bread and fruit bowls, how statin drugs may be erasing your memory, why a diet high in "good fats" is ideal, and how to spur the growth of new brain cells at any age. Dr. Perlmutter's revolutionary 4-week plan shows you how to keep your brain healthy, vibrant, and sharp while dramatically reducing your risk for debilitating neurological diseases as well as relieving more common, everyday conditions -- without drugs. Easy-to-follow strategies, delicious recipes, and weekly goals help you to put the plan into action. With a blend of anecdotes, cutting-edge research, and accessible, practical advice, Grain Brain teaches you how to take control of your "smart genes," regain wellness, and enjoy lifelong health and vitality.

Review: Tells what brain should eat - I highly recommend this book not only to people who are at the risk of getting brain disorders but also to the young generations. This book contains all the information that we have to know whenever we eat something. Readers can get advices on diet/food intake from this book without going to doctors. And those advices are not only linked to getting healthy but also to preventing the dementia or any other brain disorders. Dr. David Perlmutter does not just throw some ideas to the readers; rather he explains why it happens or how to stop it. He also explains the relation between the nutrient and brain disorder that what chemical and biological factors of nutrient are actually causing the illness. I think everyone should read this book at least once because we all depend on the food intake. The earlier you know, the more you can prevent the brain diseases. In the introduction of this book, Dr. Perlmutter includes self-assessment page where the readers can define what are their risk factors for getting brain disorders. He also explains that he would provide information useful for the following brain illness: ADHD, anxiety, depression, diabetes, epilepsy, dementia, etc. He states that he would prove to the readers about how daily habit affects the function and long-term health of brain. Part 1, "The Whole Grain Truth", discusses about the common ingredients such as wheat and fats that are both friends and enemies of the brain. It is divided into six chapters, the first three chapters discusses about the inflammation process, the role of gluten, carbohydrates and fats in inflammation, and the inflammation as the heart of brain disease. He also covers psychological and behavioral disorders that food choices can change an individual genetic characteristic and eventually leads to the brain illness. In the last chapter of part 1, the author focuses on how the gluten can impinge the long-term health and functions of the brain; people should keep breads away from them. Part 2, "The Grain Brain Rehab", mainly discusses about the science beyond the habits that support a healthy brain. Divided into three chapters, he explores the relationship of nutrition and supplements, exercise, and sleep to brain disorders individually. He recommends the dietary habits that people should follow for healthy brain: the daily exercise routine to have better genes in the brain: the sleep routine to maintain stable hormone levels. In the part 3, "Say Good-Bye to Grain Brain", the author actually recommends a month-long program with the meal plan, recipes, and weekly goal. He, in details, provides what should be taken everyday, and what must be forbidden for intake during lifetime. This recipe and diet plan would lead people to change their diet habits and help keep healthy brain consistently. In this book, the style and structure is simple and easy to follow. First, Dr. Perlmutter follows the structure of having a proposal, evidences and recommendations. He first proposes how each nutrient and daily habits can affect the health of brain. Then, he provides evidence to support his thesis by explaining the chemical and biological mechanism of each food intake and the effect of sleep and exercise. Finally, he gives a recommendation on how to avoid brain illness in the future with his own version of meal plan, recipe, and weekly goals. Therefore, people with no scientific background can all understand what the author is trying to explain. Also, whenever he introduces new biochemical concepts, he explains in-depth so that readers will not get lost. In the beginning of each chapter, he gives an overview of what will be in there. For example, in chapter 6, he gives all the list of changes that sugars can trigger in the short-term basis: behavior, seize control of focus and concentration, tic disorders and mood conditions such as depression. In terms of the style, I was able to observe the author's effort of trying to make a connection with the readers by questioning and stating his past daily habits. The readers would fully respond only if they have the same experience as the discussion topic of the author. However, there were not enough pictures or graphs that could assist the readers to understand the context. The font size and spacing was viewable. The headings were appropriately positioned and fully caught the attention of readers. I read this book to find out the relationship between diet and Alzheimer's disease. The book covered this topic with appropriate volume but the book itself actually gave full information about the effect of each nutrient and supplements on the health of brain. First, he proved that the inflammation would lead to the cause of Alzheimer's disease because of "toxic sugar inflicts"(pg. 29). The insulin resistance from sugar, "sparks the formation of those infamous plaques that are present in diseased brains", especially in Alzheimer's disease (pg. 30). Because these plaques would buildup and take place of normal brain cells, the diabetes patient will have higher chance of getting Alzheimer's disease. It was interesting to see how diabetes and Alzheimer's disease was related together. I have read several research articles about their relationship but it was interesting to find out how food intake can be a key connector between these two diseases. In the later chapter, he also discusses about the increased risk of Alzheimer's disease due to diabetes. Since diabetes are also caused by high intake of carbs and sugars, it will definitely increase the risk of Alzheimer by increasing the inflammation and triggering the formation of insoluble protein plaques. He also included a report, published in 2005, to indicate the relationship between the cholesterol level and cognitive ability. As Alzheimer's diseased patients have very low cognitive ability, I believed that high cholesterol level would actually decrease the cognition. However, he stated "people who had the highest cholesterol levels scored higher on cognitive tests than those with lower levels"(pg. 34). It was interesting to find out that there has to be a "protective factor" from cholesterol that can maintain the cognitive skills. He then defines the elevations of cytokine as the hallmarks of the Alzheimer's disease. Gluten "increases the production of inflammatory cytokines" and such inflammation can actually prevent the production of soluble proteins and deposition of unnecessary cells in the brain, increasing the formation of insoluble plaques. This book is definitely giving an advice to lose wheat and maintain low sugar level in our body. The intake of grain is actually increasing the risk of many brain disorders including ADHD, severe depression, dementia, Alzheimer's disease, etc. I would recommend this book even to the patient so that they do not have to solely depend on the medication, rather they should try a new lifestyle as Dr. Perlmutter recommends in the last chapter. This book is also recommended for young generation who has enough time to prevent the brain illness by reading this book and altering their diet plan. For potential readers, I would recommend to write current daily food intake before reading this book. By analyzing what you have eaten everyday based on this book, you would be able to find out your own risk factors to brain disorders. Also, try to read this book with whole family. Your daily food intake highly depends on family members, thus to get altered in a short term you must change your family's lifestyle.
Review: A must read for anyone who cares about their health - This is one of the most important book I have ever read on nutrition. You've known me over the years talk about nutrition and how important it is to our health but it seems that in all of my reading over the years I've only gotten a portion of the story. This book is very important because it points up the latest research connected with empirical evidence that our dependence on carbohyrates for fuel is very misguided, dangerouosly so. If you think that just by laying off the fat and sugar will do it for you, this will completely turn all of that on its head. The two main culprits to why people are so sick, overweight and full of chronic problems and diseases can be traced to our eating of gluten which all wheat products contain as do many of the other products that we eat that are processed by the food industry. The pharmaceutical and food industry does not want you to know this information because it would drastically cut into their profits. When we talk about diseases we also must talk about Alzheimer's and heart disease and cancer, migraines, digestive problems and diabetes. All of these are preventable diseases and this doctor, and MD who has been in the forefront of research, spells out and explains in detail why if you don't know this information and change your diet you are not only susceptible to heart disease cancer and a host of other problems including ALS and parkinson's, but dementia. The standard American diet (SAD) of low fat and high carbs is causing not only the obesity epidemic, but our skyrocketing rates of cancer and heart disease. He goes into statin drugs and what you need to know if you are taking them and how you are at an increased risk of dying of a heart attack and also a host of other problems. You need to read this and know this information so you can make educated decisions about your health. The majority of doctors do not know this information which has been highly researched and reported not only by the NIH but slews of medical journals. By making adjustments in your diet you can get yourself off of statins and other heart medications as well as tons of other drugs that people take to mask symptoms and not get at the root cause of the problems, many mainly of which are dietary. You need to know how gluten affects you, and you need to know how sugar and carbohydrates that turn into sugar your body affects you. Yes even too much fruit, let alone sugary soft drinks, ice cream and the like, can have deleterious effects on your entire system which can contribute to poor brain performance and even dementia. This is really a book about your brain because all of these processes and problems attributed to improper nutrition which affect your heart and other body processes ultimately affect how you think, your personality and who you are in the world. For instance, and I've never read this anywhere before if you are overweight you have a smaller brain size and each additional pound contributes to your brain shrinking. He goes into detail about why this happens and the research that proves it. The good news is that this can be reversed. The thing about this book is that it is not based on opinion but on solid scientific investigation back by years of dealing with patients who come to his office with all kinds of maladies and he is able to turn these people's lives around simply by educating them and changing their diet. So as I said I highly recommend getting this book, sitting down and reading this is quickly as you can with a highliter. You will want to know this information so you can help yourself, your family and friends for if anyone is eating the SAD which is full of wheat, high carbs and low fat if they are not suffering now then they will be. Inflammation happens in the brain anyway, and the thing is we can't feel it so we are now aware of it. But almost everyone deals in some degree with headaches, depression, sleep problems, weight problems, circulatory problems. Do yourself and favor and get this book now. It will be the best 10 bucks you spend all year. This is a game changer and should be read by everyone. It is that important. Having this knowledge and adjusting the diet accordingly will assure that you will continue in your life to be in optimal without fear of heart disease, cancer or dementia. You will have it figured out. No more secrets and you will see how the pharmaceutical industry and the food industry will lose vast amounts of money if the general population knew this information and started living accordingly. You will no longer be living in the dark. You will know that if you choose to continue to eat in a manner that does not support your overall health you have no one to blame but yourself.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Best Sellers Rank | #50,782 in Books ( See Top 100 in Books ) #33 in Nervous System Diseases (Books) #39 in Alzheimer's #59 in Dementia |
| Customer Reviews | 4.6 out of 5 stars 11,302 Reviews |

## Images

![Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers - Image 1](https://m.media-amazon.com/images/I/71Wl-32p8TL.jpg)

## Customer Reviews

### ⭐⭐⭐⭐⭐ Tells what brain should eat
*by D***O on September 30, 2013*

I highly recommend this book not only to people who are at the risk of getting brain disorders but also to the young generations. This book contains all the information that we have to know whenever we eat something. Readers can get advices on diet/food intake from this book without going to doctors. And those advices are not only linked to getting healthy but also to preventing the dementia or any other brain disorders. Dr. David Perlmutter does not just throw some ideas to the readers; rather he explains why it happens or how to stop it. He also explains the relation between the nutrient and brain disorder that what chemical and biological factors of nutrient are actually causing the illness. I think everyone should read this book at least once because we all depend on the food intake. The earlier you know, the more you can prevent the brain diseases. In the introduction of this book, Dr. Perlmutter includes self-assessment page where the readers can define what are their risk factors for getting brain disorders. He also explains that he would provide information useful for the following brain illness: ADHD, anxiety, depression, diabetes, epilepsy, dementia, etc. He states that he would prove to the readers about how daily habit affects the function and long-term health of brain. Part 1, "The Whole Grain Truth", discusses about the common ingredients such as wheat and fats that are both friends and enemies of the brain. It is divided into six chapters, the first three chapters discusses about the inflammation process, the role of gluten, carbohydrates and fats in inflammation, and the inflammation as the heart of brain disease. He also covers psychological and behavioral disorders that food choices can change an individual genetic characteristic and eventually leads to the brain illness. In the last chapter of part 1, the author focuses on how the gluten can impinge the long-term health and functions of the brain; people should keep breads away from them. Part 2, "The Grain Brain Rehab", mainly discusses about the science beyond the habits that support a healthy brain. Divided into three chapters, he explores the relationship of nutrition and supplements, exercise, and sleep to brain disorders individually. He recommends the dietary habits that people should follow for healthy brain: the daily exercise routine to have better genes in the brain: the sleep routine to maintain stable hormone levels. In the part 3, "Say Good-Bye to Grain Brain", the author actually recommends a month-long program with the meal plan, recipes, and weekly goal. He, in details, provides what should be taken everyday, and what must be forbidden for intake during lifetime. This recipe and diet plan would lead people to change their diet habits and help keep healthy brain consistently. In this book, the style and structure is simple and easy to follow. First, Dr. Perlmutter follows the structure of having a proposal, evidences and recommendations. He first proposes how each nutrient and daily habits can affect the health of brain. Then, he provides evidence to support his thesis by explaining the chemical and biological mechanism of each food intake and the effect of sleep and exercise. Finally, he gives a recommendation on how to avoid brain illness in the future with his own version of meal plan, recipe, and weekly goals. Therefore, people with no scientific background can all understand what the author is trying to explain. Also, whenever he introduces new biochemical concepts, he explains in-depth so that readers will not get lost. In the beginning of each chapter, he gives an overview of what will be in there. For example, in chapter 6, he gives all the list of changes that sugars can trigger in the short-term basis: behavior, seize control of focus and concentration, tic disorders and mood conditions such as depression. In terms of the style, I was able to observe the author's effort of trying to make a connection with the readers by questioning and stating his past daily habits. The readers would fully respond only if they have the same experience as the discussion topic of the author. However, there were not enough pictures or graphs that could assist the readers to understand the context. The font size and spacing was viewable. The headings were appropriately positioned and fully caught the attention of readers. I read this book to find out the relationship between diet and Alzheimer's disease. The book covered this topic with appropriate volume but the book itself actually gave full information about the effect of each nutrient and supplements on the health of brain. First, he proved that the inflammation would lead to the cause of Alzheimer's disease because of "toxic sugar inflicts"(pg. 29). The insulin resistance from sugar, "sparks the formation of those infamous plaques that are present in diseased brains", especially in Alzheimer's disease (pg. 30). Because these plaques would buildup and take place of normal brain cells, the diabetes patient will have higher chance of getting Alzheimer's disease. It was interesting to see how diabetes and Alzheimer's disease was related together. I have read several research articles about their relationship but it was interesting to find out how food intake can be a key connector between these two diseases. In the later chapter, he also discusses about the increased risk of Alzheimer's disease due to diabetes. Since diabetes are also caused by high intake of carbs and sugars, it will definitely increase the risk of Alzheimer by increasing the inflammation and triggering the formation of insoluble protein plaques. He also included a report, published in 2005, to indicate the relationship between the cholesterol level and cognitive ability. As Alzheimer's diseased patients have very low cognitive ability, I believed that high cholesterol level would actually decrease the cognition. However, he stated "people who had the highest cholesterol levels scored higher on cognitive tests than those with lower levels"(pg. 34). It was interesting to find out that there has to be a "protective factor" from cholesterol that can maintain the cognitive skills. He then defines the elevations of cytokine as the hallmarks of the Alzheimer's disease. Gluten "increases the production of inflammatory cytokines" and such inflammation can actually prevent the production of soluble proteins and deposition of unnecessary cells in the brain, increasing the formation of insoluble plaques. This book is definitely giving an advice to lose wheat and maintain low sugar level in our body. The intake of grain is actually increasing the risk of many brain disorders including ADHD, severe depression, dementia, Alzheimer's disease, etc. I would recommend this book even to the patient so that they do not have to solely depend on the medication, rather they should try a new lifestyle as Dr. Perlmutter recommends in the last chapter. This book is also recommended for young generation who has enough time to prevent the brain illness by reading this book and altering their diet plan. For potential readers, I would recommend to write current daily food intake before reading this book. By analyzing what you have eaten everyday based on this book, you would be able to find out your own risk factors to brain disorders. Also, try to read this book with whole family. Your daily food intake highly depends on family members, thus to get altered in a short term you must change your family's lifestyle.

### ⭐⭐⭐⭐⭐ A must read for anyone who cares about their health
*by R***U on September 29, 2014*

This is one of the most important book I have ever read on nutrition. You've known me over the years talk about nutrition and how important it is to our health but it seems that in all of my reading over the years I've only gotten a portion of the story. This book is very important because it points up the latest research connected with empirical evidence that our dependence on carbohyrates for fuel is very misguided, dangerouosly so. If you think that just by laying off the fat and sugar will do it for you, this will completely turn all of that on its head. The two main culprits to why people are so sick, overweight and full of chronic problems and diseases can be traced to our eating of gluten which all wheat products contain as do many of the other products that we eat that are processed by the food industry. The pharmaceutical and food industry does not want you to know this information because it would drastically cut into their profits. When we talk about diseases we also must talk about Alzheimer's and heart disease and cancer, migraines, digestive problems and diabetes. All of these are preventable diseases and this doctor, and MD who has been in the forefront of research, spells out and explains in detail why if you don't know this information and change your diet you are not only susceptible to heart disease cancer and a host of other problems including ALS and parkinson's, but dementia. The standard American diet (SAD) of low fat and high carbs is causing not only the obesity epidemic, but our skyrocketing rates of cancer and heart disease. He goes into statin drugs and what you need to know if you are taking them and how you are at an increased risk of dying of a heart attack and also a host of other problems. You need to read this and know this information so you can make educated decisions about your health. The majority of doctors do not know this information which has been highly researched and reported not only by the NIH but slews of medical journals. By making adjustments in your diet you can get yourself off of statins and other heart medications as well as tons of other drugs that people take to mask symptoms and not get at the root cause of the problems, many mainly of which are dietary. You need to know how gluten affects you, and you need to know how sugar and carbohydrates that turn into sugar your body affects you. Yes even too much fruit, let alone sugary soft drinks, ice cream and the like, can have deleterious effects on your entire system which can contribute to poor brain performance and even dementia. This is really a book about your brain because all of these processes and problems attributed to improper nutrition which affect your heart and other body processes ultimately affect how you think, your personality and who you are in the world. For instance, and I've never read this anywhere before if you are overweight you have a smaller brain size and each additional pound contributes to your brain shrinking. He goes into detail about why this happens and the research that proves it. The good news is that this can be reversed. The thing about this book is that it is not based on opinion but on solid scientific investigation back by years of dealing with patients who come to his office with all kinds of maladies and he is able to turn these people's lives around simply by educating them and changing their diet. So as I said I highly recommend getting this book, sitting down and reading this is quickly as you can with a highliter. You will want to know this information so you can help yourself, your family and friends for if anyone is eating the SAD which is full of wheat, high carbs and low fat if they are not suffering now then they will be. Inflammation happens in the brain anyway, and the thing is we can't feel it so we are now aware of it. But almost everyone deals in some degree with headaches, depression, sleep problems, weight problems, circulatory problems. Do yourself and favor and get this book now. It will be the best 10 bucks you spend all year. This is a game changer and should be read by everyone. It is that important. Having this knowledge and adjusting the diet accordingly will assure that you will continue in your life to be in optimal without fear of heart disease, cancer or dementia. You will have it figured out. No more secrets and you will see how the pharmaceutical industry and the food industry will lose vast amounts of money if the general population knew this information and started living accordingly. You will no longer be living in the dark. You will know that if you choose to continue to eat in a manner that does not support your overall health you have no one to blame but yourself.

### ⭐⭐⭐⭐ Change Your Diet, Heal Your Brain
*by A***R on December 19, 2013*

I first heard of Dr. Perlmutter when he was interviewed on the podcast of Paleo diet exponent Robb Wolf. Intrigued, I wanted to know more about Dr. P's experiences in working with neurologically-challenged individuals. What impressed me first off was the fact that he is credentialed in two distinct medical specialties, neurology and nutrition. This lends great weight to his ideas, although his three decades of clinical and research-based experience lend even more. Grain Brain is written in a popular science style that is somewhat repetitive and simplistic. However, given that Dr. P's aim is to reach the widest possible audience, this shortcoming can be forgiven. On the plus side, the writing style makes his message and purpose very accessible. (It is because of the writing style that I've given the book 4 stars instead of 5.) A couple of important points stand out. First, some form of gluten intolerance, sensitivity or allergy, either celiac or otherwise, exists in a huge number of people who are currently undiagnosed and who may not be experiencing gastrointestinal symptoms. Instead, their symptoms may be neurological, including everything from ADHD to Alzheimer's and Tourette's. So, the first thing Dr. P. does for a new patient is look for gluten intolerance, using bloodwork that tests for many biochemical markers in addition to the one we all know about, celiac disease. So here's the first useful takeaway: one can be sensitive to wheat without having celiac disease, and this sensitivity will reveal itself in a blood test. Once the sensitivity is confirmed, eliminating gluten from the diet is often the only treatment required to resolve formerly intractable problems like chronic migraine. Second, Dr. P. tackles the issues of cholesterol and carbohydrates and their relationship to heart disease, type 2 diabetes and obesity as well as rising rates of dementia in the elderly. Here he wades into the major bugaboo of current nutritional debate, the role of fats in the diet. He provides a fairly good scientific analysis of the issue with some clinical and research references, although I wish he had been more thorough in this aspect of his work, because it is so important. (See my comment above about the "popular science" tone of the book.) Nevertheless, he makes a very strong case for why we've had it all wrong with respect to fats and cholesterol for a good half-century. As a neurologist, the brain is his domain, and as an expert in nutrition as well, he's in an excellent position to explain what the brain is made of (fat and cholesterol) and what the brain needs to function properly (more of same). When we deprive our bodies of good fats, such as those found in coconut, avocado, walnuts, fish and grass-fed beef, we deprive ourselves of the fuel we need to think, and literally, live. Conversely, Dr. P. demonstrates the problem with a high-carbohydrate diet and its pernicious effect on the brain, endocrine system and cell structure. Want to lose weight or heal type 2 diabetes? Look at your carbohydrate intake. Generally speaking, Dr. P.'s aim is to educate us regarding the correlation between diet and such conditions as Alzheimer's disease, senile dementia, type 2 diabetes, obesity and heart disease. He has a lot to say about physiology and nutrition, about the way our bodies process fats, carbs and protein. You will be a much better informed consumer for reading Grain Brain. Dr. P. is not an absolutist. He explains that it is still possible to be vegetarian or vegan and eat in a way that supplies the brain and body with all the nutrition it needs. Given his fairly broad condemnation of carbohydrates, I don't totally understand this equivocation. But I believe that Dr. P. is trying to reach the widest possible audience, and he's a realist. Not everybody wants to eat meat, and this fact cannot and should not exclude them from this discussion. (Vegetarians and vegans suffer from obesity and have heart attacks too.) There has to be wiggle-room in a dietary protocol, because in truth, there is no one-size-fits-all when it comes to diet. In this regard, Dr. P. is not rigid or dogmatic, and this speaks favorably of him. As part of his holistic approach, Dr. P. devotes considerable space to the importance of sleep, exercise and occasional, controlled fasting, backed up by statistics and research. Finally, Dr. P. provides a concrete program on how to transform your diet. Although he is not a huge fan of supplementation, he provides a short list of supplements that he feels are essential to brain health. His advice is specific enough that you can start tomorrow, follow his guidelines, and experiment with his suggestions on your own. Unlike many so-called nutrition experts, Dr. Perlmutter is a Board-certified Neurologist and a Fellow of the American College of Nutrition who has utilized his protocol to heal very sick people for decades. His viewpoint is science-based and backed up by experience. There is a lot of terrific information in this book. It's a great place to start if you're suffering from chronic conditions, want to lose weight, are concerned about your mental status, or simply want to set yourself up for a lifetime of good health.

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