Hordenine is one of the most interesting naturally derived energizing Nootropics available today. It can be found in a large number of fruits and plants, but it is most commonly extracted from the Bitter Orange, a fruit endemic to China and the Mediterranean. Benefits and Effects 1. Mood enhancing By 'blocking' the MAOB enzyme, hordenine is able to increase dopamine levels. Dopamine has long been associated with increases in mood and pleasure. 2. Energizing The second most important benefit of a hordenine supplement is its ability to increase your energy levels. Hordenine does this by reversing the metabolism of norepinephrine. 3. Taken with Phenylethylamine The problem with PEA is that it is degraded by your enzymes very rapidly. PEA effects only last for around 1-2 hours when taken alone. However, using hordenine with PEA helps to strengthen the effects of both substances, while also increasing the length of the effects of PEA. Recommended Usage The recommended dosage for hordenine is around 30 mg daily. Side effects and warnings Hordenine is a very safe supplement when used correctly. Do not take hordenine if you are using other stimulants or are on MAOI medication. References "Hordenine", Examine, retrieved 21-12-2014 "Deamination of hordenine... " Barwell CJ1, Basma AN, Lafi MA, Leake LD, J Pharm Pharmacol. 1989 Jun;41(6):421-3. "Norepinephrine" Rice Computational and Applied Mathematics University notes "Pharmacological effects of hordenine" Hapke HJ, Strathmann W, Dtsch Tierarztl Wochenschr. 1995 Jun;102(6):228-32. "Selective inhibitors ..." Finberg JP, Gillman K, Int Rev Neurobiol. 2011;100:169-90.
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